Drug interactions
Mavacamten + Progesterone
Severity: Major
Mavacamten and Progesterone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mavacamten may induce CYP3A4 and lower progestogen exposure. This can cause breakthrough bleeding, inadequate endometrial protection or contraceptive failure.
What this interaction means in plain words
Mavacamten and Progesterone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mavacamten belongs to Cardiovascular; Progesterone belongs to Endocrine.
Why it happens
Mavacamten induces CYP3A4 and increases progesterone metabolism, lowering its exposure.
What to do
Use a contraceptive method not affected by enzyme induction, such as an intrauterine system, or add a barrier method during therapy and for several months after stopping mavacamten. Monitor for bleeding irregularities when progesterone is used for other indications.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Progesterone
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Mavacamten with Progesterone?
MediHelp rates the interaction as major. Mavacamten and Progesterone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mavacamten may induce CYP3A4 and lower progestogen exposure. This can cause breakthrough bleeding, inadequate endometrial protection or contraceptive failure.
How serious is the interaction between Mavacamten and Progesterone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a contraceptive method not affected by enzyme induction, such as an intrauterine system, or add a barrier method during therapy and for several months after stopping mavacamten. Monitor for bleeding irregularities when progesterone is used for other indications.
What other medicines interact with Progesterone?
MediHelp also lists interactions of Progesterone with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Progesterone page.
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