Drug interactions
Mitotane + Progesterone
Severity: Major
Mitotane and Progesterone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitotane is a strong CYP3A4 inducer and substantially lowers progesterone concentrations. This may lead to loss of progestogenic effect such as endometrial protection or pregnancy support.
What this interaction means in plain words
Mitotane and Progesterone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mitotane belongs to Oncology; Progesterone belongs to Endocrine.
Why it happens
Mitotane induces CYP3A4, accelerating progesterone metabolism, with effects that persist after mitotane is stopped.
What to do
Monitor for loss of efficacy and consider higher progesterone doses or an alternative therapy. Mitotane induction may last for weeks after discontinuation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Progesterone
Other interactions of Mitotane
- Doravirine + Mitotane Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Lorlatinib + Mitotane Contraindicated
- Abiraterone + Mitotane Major
- Apixaban + Mitotane Major
- Aprepitant + Mitotane Major
Frequently asked questions
Can I take Mitotane with Progesterone?
MediHelp rates the interaction as major. Mitotane and Progesterone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mitotane is a strong CYP3A4 inducer and substantially lowers progesterone concentrations. This may lead to loss of progestogenic effect such as endometrial protection or pregnancy support.
How serious is the interaction between Mitotane and Progesterone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of efficacy and consider higher progesterone doses or an alternative therapy. Mitotane induction may last for weeks after discontinuation.
What other medicines interact with Progesterone?
MediHelp also lists interactions of Progesterone with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Progesterone page.
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