Drug interactions
Betrixaban + Ticlopidine
Severity: Major
Betrixaban and Ticlopidine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an antiplatelet with a factor Xa inhibitor increases the risk of clinically important bleeding. Ticlopidine also carries its own hematologic toxicity.
What this interaction means in plain words
Betrixaban and Ticlopidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic effects of platelet inhibition and factor Xa inhibition.
What to do
Avoid the combination unless clearly indicated; if used, monitor for bleeding and check blood counts regularly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ticlopidine
Frequently asked questions
Can I take Betrixaban with Ticlopidine?
MediHelp rates the interaction as major. Betrixaban and Ticlopidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an antiplatelet with a factor Xa inhibitor increases the risk of clinically important bleeding. Ticlopidine also carries its own hematologic toxicity.
How serious is the interaction between Betrixaban and Ticlopidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination unless clearly indicated; if used, monitor for bleeding and check blood counts regularly.
What other medicines interact with Ticlopidine?
MediHelp also lists interactions of Ticlopidine with, for example, Mavacamten, Abrocitinib, Acetylsalicylic acid. The full list is on the Ticlopidine page.
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