Drug interactions
Betrixaban + Vilazodone
Severity: Moderate
Betrixaban and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilazodone, a serotonergic antidepressant, can impair platelet function by depleting platelet serotonin. When given with the factor Xa inhibitor betrixaban, the risk of bleeding, including gastrointestinal bleeding, may increase.
What this interaction means in plain words
Betrixaban and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effect: impaired serotonin-dependent platelet aggregation plus factor Xa inhibition.
What to do
Monitor for signs of bleeding and check hemoglobin if symptoms arise. Counsel the patient to report bruising, black stools or other bleeding promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Frequently asked questions
Can I take Betrixaban with Vilazodone?
MediHelp rates the interaction as moderate. Betrixaban and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilazodone, a serotonergic antidepressant, can impair platelet function by depleting platelet serotonin. When given with the factor Xa inhibitor betrixaban, the risk of bleeding, including gastrointestinal bleeding, may increase.
How serious is the interaction between Betrixaban and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and check hemoglobin if symptoms arise. Counsel the patient to report bruising, black stools or other bleeding promptly.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
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