Drug interactions
Selegiline + Vilazodone
Severity: Contraindicated
Selegiline and Vilazodone: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining vilazodone with selegiline may cause serotonin syndrome, particularly with oral higher doses or the transdermal patch where MAO-A is also inhibited. The reaction can be life-threatening.
What this interaction means in plain words
Selegiline and Vilazodone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Selegiline belongs to Central Nervous System; Vilazodone belongs to Central Nervous System.
Why it happens
Additive serotonergic effects from MAO inhibition and serotonin reuptake inhibition.
What to do
Do not co-administer. Observe a 14 day gap after stopping selegiline before starting vilazodone and a 14 day gap after stopping vilazodone before starting selegiline.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Tranylcypromine + Vilazodone Contraindicated
Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Selegiline with Vilazodone?
MediHelp rates the interaction as contraindicated. Selegiline and Vilazodone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining vilazodone with selegiline may cause serotonin syndrome, particularly with oral higher doses or the transdermal patch where MAO-A is also inhibited. The reaction can be life-threatening.
How serious is the interaction between Selegiline and Vilazodone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Observe a 14 day gap after stopping selegiline before starting vilazodone and a 14 day gap after stopping vilazodone before starting selegiline.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
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