Drug interactions
Selegiline transdermal + Vilazodone
Severity: Contraindicated
Selegiline transdermal and Vilazodone: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilazodone is a serotonin reuptake inhibitor and 5-HT1A partial agonist, and selegiline is a monoamine oxidase inhibitor that at antidepressant doses is not selective. Combining them can produce serotonin syndrome with hyperthermia, agitation, myoclonus, autonomic instability and seizures.
What this interaction means in plain words
Selegiline transdermal and Vilazodone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive serotonergic activity from serotonin reuptake inhibition plus inhibition of serotonin breakdown by MAO.
What to do
Do not coadminister. Allow at least 14 days between stopping an MAOI and starting vilazodone, and at least 14 days after stopping vilazodone before starting selegiline.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
- Tranylcypromine + Vilazodone Contraindicated
Frequently asked questions
Can I take Selegiline transdermal with Vilazodone?
MediHelp rates the interaction as contraindicated. Selegiline transdermal and Vilazodone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Vilazodone is a serotonin reuptake inhibitor and 5-HT1A partial agonist, and selegiline is a monoamine oxidase inhibitor that at antidepressant doses is not selective. Combining them can produce serotonin syndrome with hyperthermia, agitation, myoclonus, autonomic instability and seizures.
How serious is the interaction between Selegiline transdermal and Vilazodone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister. Allow at least 14 days between stopping an MAOI and starting vilazodone, and at least 14 days after stopping vilazodone before starting selegiline.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
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