Drug interactions
Phenelzine + Vilazodone
Severity: Contraindicated
Phenelzine and Vilazodone: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilazodone with phenelzine can cause serotonin syndrome, which may be severe or fatal. Labeling contraindicates use with MAO inhibitors.
What this interaction means in plain words
Phenelzine and Vilazodone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Phenelzine belongs to Central Nervous System; Vilazodone belongs to Central Nervous System.
Why it happens
Additive serotonergic effect from serotonin reuptake inhibition and partial 5-HT1A agonism by vilazodone with MAO inhibition.
What to do
Never combine. Wait at least 14 days after stopping phenelzine before starting vilazodone, and at least 14 days after stopping vilazodone before starting phenelzine.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
- Tranylcypromine + Vilazodone Contraindicated
Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Frequently asked questions
Can I take Phenelzine with Vilazodone?
MediHelp rates the interaction as contraindicated. Phenelzine and Vilazodone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Vilazodone with phenelzine can cause serotonin syndrome, which may be severe or fatal. Labeling contraindicates use with MAO inhibitors.
How serious is the interaction between Phenelzine and Vilazodone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Never combine. Wait at least 14 days after stopping phenelzine before starting vilazodone, and at least 14 days after stopping vilazodone before starting phenelzine.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Rasagiline. The full list is on the Vilazodone page.
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