Drug interactions
Rasagiline + Vilazodone
Severity: Contraindicated
Rasagiline and Vilazodone: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilazodone taken with rasagiline raises the risk of serotonin syndrome. Labeling for vilazodone prohibits use with MAO inhibitors, including those that are MAO-B selective.
What this interaction means in plain words
Rasagiline and Vilazodone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Rasagiline belongs to Central Nervous System; Vilazodone belongs to Central Nervous System.
Why it happens
Additive serotonergic activity from vilazodone's reuptake inhibition and MAO inhibition by rasagiline.
What to do
Avoid concurrent use. Allow 14 days after stopping rasagiline before starting vilazodone, and 14 days after stopping vilazodone before starting rasagiline.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
- Tranylcypromine + Vilazodone Contraindicated
Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Rasagiline with Vilazodone?
MediHelp rates the interaction as contraindicated. Rasagiline and Vilazodone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Vilazodone taken with rasagiline raises the risk of serotonin syndrome. Labeling for vilazodone prohibits use with MAO inhibitors, including those that are MAO-B selective.
How serious is the interaction between Rasagiline and Vilazodone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use. Allow 14 days after stopping rasagiline before starting vilazodone, and 14 days after stopping vilazodone before starting rasagiline.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
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