Drug interactions
Bevacizumab + Epirubicin
Severity: Moderate
Bevacizumab and Epirubicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both can contribute to cardiac toxicity, and bevacizumab is associated with heart failure and hypertension. Used with an anthracycline, the risk of cardiac dysfunction may increase.
What this interaction means in plain words
Bevacizumab and Epirubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bevacizumab belongs to Oncology; Epirubicin belongs to Oncology.
Why it happens
Additive cardiotoxicity from anthracycline myocardial injury and bevacizumab-related hypertension and cardiomyopathy.
What to do
Assess baseline LVEF and monitor cardiac function and blood pressure periodically during treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Epirubicin
- Adenovirus types 4 and 7 live + Epirubicin Contraindicated
- Belatacept + Epirubicin Major
- Cimetidine + Epirubicin Major
- Deferiprone + Epirubicin Major
- Dengue vaccine + Epirubicin Major
- Epirubicin + Etrasimod Major
Other interactions of Bevacizumab
- Bevacizumab + Sunitinib Major
- Bevacizumab + Daunorubicin Moderate
- Bevacizumab + Dengue vaccine Moderate
- Bevacizumab + Doxorubicin Moderate
- Bevacizumab + Doxorubicin liposomal Moderate
- Bevacizumab + Efgartigimod / hyaluronidase sc Moderate
Frequently asked questions
Can I take Bevacizumab with Epirubicin?
MediHelp rates the interaction as moderate. Bevacizumab and Epirubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both can contribute to cardiac toxicity, and bevacizumab is associated with heart failure and hypertension. Used with an anthracycline, the risk of cardiac dysfunction may increase.
How serious is the interaction between Bevacizumab and Epirubicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess baseline LVEF and monitor cardiac function and blood pressure periodically during treatment.
What other medicines interact with Epirubicin?
MediHelp also lists interactions of Epirubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cimetidine. The full list is on the Epirubicin page.
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