Drug interactions
Bexarotene + Fluconazole
Severity: Moderate
Bexarotene and Fluconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bexarotene is metabolized in part by CYP3A4, so fluconazole may raise its concentrations. This can increase dose-related toxicity such as hypertriglyceridemia, hypothyroidism and liver enzyme elevation.
What this interaction means in plain words
Bexarotene and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bexarotene belongs to Oncology; Fluconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4 metabolism of bexarotene by fluconazole.
What to do
Monitor lipids, thyroid function and liver tests more closely during the combination. Reduce the bexarotene dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Bexarotene
- Bexarotene + Gemfibrozil Major
- Bexarotene + Lorlatinib Major
- Alogliptin-pioglitazone + Bexarotene Moderate
- Amobarbital + Bexarotene Moderate
- Aprepitant + Bexarotene Moderate
- Axitinib + Bexarotene Moderate
Frequently asked questions
Can I take Bexarotene with Fluconazole?
MediHelp rates the interaction as moderate. Bexarotene and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bexarotene is metabolized in part by CYP3A4, so fluconazole may raise its concentrations. This can increase dose-related toxicity such as hypertriglyceridemia, hypothyroidism and liver enzyme elevation.
How serious is the interaction between Bexarotene and Fluconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor lipids, thyroid function and liver tests more closely during the combination. Reduce the bexarotene dose if toxicity develops.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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