Drug interactions
Bicalutamide + Bosutinib
Severity: Minor
Bicalutamide and Bosutinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bicalutamide may weakly inhibit CYP3A4 and slightly raise bosutinib exposure, which is a CYP3A4 substrate. The effect is probably small, but bosutinib toxicities include diarrhea and hepatotoxicity.
What this interaction means in plain words
Bicalutamide and Bosutinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bicalutamide belongs to Endocrine; Bosutinib belongs to Oncology.
Why it happens
Weak possible CYP3A4 inhibition by bicalutamide reduces bosutinib metabolism.
What to do
Monitor liver enzymes and gastrointestinal tolerance as is routine with bosutinib; no dose change is usually needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bicalutamide and Bosutinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Bicalutamide
- Bicalutamide + Lomitapide Major
- Aminolevulinic acid + Bicalutamide Moderate
- Bicalutamide + Eliglustat Moderate
- Bicalutamide + Flibanserin Moderate
- Bicalutamide + Ivosidenib Moderate
- Bicalutamide + Lonafarnib Moderate
Other interactions of Bosutinib
- Amiodarone + Bosutinib Major
- Apalutamide + Bosutinib Major
- Aprepitant + Bosutinib Major
- Bosentan + Bosutinib Major
- Bosutinib + Carbamazepine Major
- Bosutinib + Chlorpromazine Major
Frequently asked questions
Can I take Bicalutamide with Bosutinib?
MediHelp rates the interaction as minor. Bicalutamide and Bosutinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bicalutamide may weakly inhibit CYP3A4 and slightly raise bosutinib exposure, which is a CYP3A4 substrate. The effect is probably small, but bosutinib toxicities include diarrhea and hepatotoxicity.
How serious is the interaction between Bicalutamide and Bosutinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and gastrointestinal tolerance as is routine with bosutinib; no dose change is usually needed.
What other medicines interact with Bicalutamide?
MediHelp also lists interactions of Bicalutamide with, for example, Lomitapide, Aminolevulinic acid, Eliglustat. The full list is on the Bicalutamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
