Drug interactions
Bicalutamide + Cabazitaxel
Severity: Minor
Bicalutamide and Cabazitaxel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bicalutamide is a weak CYP3A4 inhibitor in vitro, and cabazitaxel is a CYP3A4 substrate. Clinically significant increases are unlikely, and the two are commonly used in prostate cancer.
What this interaction means in plain words
Bicalutamide and Cabazitaxel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bicalutamide belongs to Endocrine; Cabazitaxel belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition by bicalutamide may slightly reduce cabazitaxel metabolism.
What to do
No dose adjustment is needed; monitor neutrophil counts as per routine cabazitaxel care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bicalutamide
- Bicalutamide + Lomitapide Major
- Aminolevulinic acid + Bicalutamide Moderate
- Bicalutamide + Eliglustat Moderate
- Bicalutamide + Flibanserin Moderate
- Bicalutamide + Ivosidenib Moderate
- Bicalutamide + Lonafarnib Moderate
Other interactions of Cabazitaxel
Frequently asked questions
Can I take Bicalutamide with Cabazitaxel?
MediHelp rates the interaction as minor. Bicalutamide and Cabazitaxel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bicalutamide is a weak CYP3A4 inhibitor in vitro, and cabazitaxel is a CYP3A4 substrate. Clinically significant increases are unlikely, and the two are commonly used in prostate cancer.
How serious is the interaction between Bicalutamide and Cabazitaxel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor neutrophil counts as per routine cabazitaxel care.
What other medicines interact with Bicalutamide?
MediHelp also lists interactions of Bicalutamide with, for example, Lomitapide, Aminolevulinic acid, Eliglustat. The full list is on the Bicalutamide page.
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