Drug interactions
Bicalutamide + Dutasteride-tamsulosin
Severity: Minor
Bicalutamide and Dutasteride-tamsulosin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bicalutamide is a weak CYP3A4 inhibitor in vitro, and the clinical effect on tamsulosin or dutasteride exposure is unlikely to be meaningful. Any rise in tamsulosin levels would be small. Both drugs are also uncommonly used together because of opposing prostate indications.
What this interaction means in plain words
Bicalutamide and Dutasteride-tamsulosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bicalutamide belongs to Endocrine; Dutasteride-tamsulosin belongs to Genitourinary.
Why it happens
Weak CYP3A4 inhibition by bicalutamide may slightly reduce tamsulosin clearance.
What to do
No dose adjustment is needed. Ask the patient about dizziness or orthostatic symptoms at routine visits.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dutasteride-tamsulosin
Other interactions of Bicalutamide
- Bicalutamide + Lomitapide Major
- Aminolevulinic acid + Bicalutamide Moderate
- Bicalutamide + Eliglustat Moderate
- Bicalutamide + Flibanserin Moderate
- Bicalutamide + Ivosidenib Moderate
- Bicalutamide + Lonafarnib Moderate
Frequently asked questions
Can I take Bicalutamide with Dutasteride-tamsulosin?
MediHelp rates the interaction as minor. Bicalutamide and Dutasteride-tamsulosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bicalutamide is a weak CYP3A4 inhibitor in vitro, and the clinical effect on tamsulosin or dutasteride exposure is unlikely to be meaningful. Any rise in tamsulosin levels would be small. Both drugs are also uncommonly used together because of opposing prostate indications.
How serious is the interaction between Bicalutamide and Dutasteride-tamsulosin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Ask the patient about dizziness or orthostatic symptoms at routine visits.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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