Drug interactions
Bicalutamide + Elacestrant
Severity: Minor
Bicalutamide and Elacestrant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bicalutamide may weakly inhibit CYP3A4 and slightly raise elacestrant exposure. The effect is probably small and unlikely to be clinically significant.
What this interaction means in plain words
Bicalutamide and Elacestrant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bicalutamide belongs to Endocrine; Elacestrant belongs to Oncology.
Why it happens
Weak possible CYP3A4 inhibition by bicalutamide reduces elacestrant metabolism.
What to do
No dose adjustment is usually needed; monitor for nausea and other elacestrant adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bicalutamide
- Bicalutamide + Lomitapide Major
- Aminolevulinic acid + Bicalutamide Moderate
- Bicalutamide + Eliglustat Moderate
- Bicalutamide + Flibanserin Moderate
- Bicalutamide + Ivosidenib Moderate
- Bicalutamide + Lonafarnib Moderate
Other interactions of Elacestrant
Frequently asked questions
Can I take Bicalutamide with Elacestrant?
MediHelp rates the interaction as minor. Bicalutamide and Elacestrant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bicalutamide may weakly inhibit CYP3A4 and slightly raise elacestrant exposure. The effect is probably small and unlikely to be clinically significant.
How serious is the interaction between Bicalutamide and Elacestrant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed; monitor for nausea and other elacestrant adverse effects.
What other medicines interact with Bicalutamide?
MediHelp also lists interactions of Bicalutamide with, for example, Lomitapide, Aminolevulinic acid, Eliglustat. The full list is on the Bicalutamide page.
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