Drug interactions
Bicalutamide + Isavuconazonium
Severity: Minor
Bicalutamide and Isavuconazonium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole is a CYP3A4 substrate, and bicalutamide may slightly raise its concentration. Clinical impact is expected to be small.
What this interaction means in plain words
Bicalutamide and Isavuconazonium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bicalutamide belongs to Endocrine; Isavuconazonium belongs to Anti Fungals.
Why it happens
Weak CYP3A4 inhibition by bicalutamide reduces isavuconazole clearance slightly.
What to do
No routine adjustment; monitor for isavuconazole adverse effects such as liver enzyme elevation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bicalutamide
- Bicalutamide + Lomitapide Major
- Aminolevulinic acid + Bicalutamide Moderate
- Bicalutamide + Eliglustat Moderate
- Bicalutamide + Flibanserin Moderate
- Bicalutamide + Ivosidenib Moderate
- Bicalutamide + Lonafarnib Moderate
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Bicalutamide with Isavuconazonium?
MediHelp rates the interaction as minor. Bicalutamide and Isavuconazonium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isavuconazole is a CYP3A4 substrate, and bicalutamide may slightly raise its concentration. Clinical impact is expected to be small.
How serious is the interaction between Bicalutamide and Isavuconazonium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment; monitor for isavuconazole adverse effects such as liver enzyme elevation.
What other medicines interact with Bicalutamide?
MediHelp also lists interactions of Bicalutamide with, for example, Lomitapide, Aminolevulinic acid, Eliglustat. The full list is on the Bicalutamide page.
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