Drug interactions
Bicalutamide + Sparsentan
Severity: Minor
Bicalutamide and Sparsentan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sparsentan is a CYP3A4 substrate, and moderate inhibitors can raise its exposure. Bicalutamide is a weak inhibitor, so the effect is expected to be small.
What this interaction means in plain words
Bicalutamide and Sparsentan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bicalutamide belongs to Endocrine; Sparsentan belongs to Genitourinary.
Why it happens
Weak CYP3A4 inhibition by bicalutamide may modestly raise sparsentan levels.
What to do
No dose change; monitor blood pressure, potassium, edema and liver and kidney function as routinely required for sparsentan.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bicalutamide
- Bicalutamide + Lomitapide Major
- Aminolevulinic acid + Bicalutamide Moderate
- Bicalutamide + Eliglustat Moderate
- Bicalutamide + Flibanserin Moderate
- Bicalutamide + Ivosidenib Moderate
- Bicalutamide + Lonafarnib Moderate
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Bicalutamide with Sparsentan?
MediHelp rates the interaction as minor. Bicalutamide and Sparsentan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sparsentan is a CYP3A4 substrate, and moderate inhibitors can raise its exposure. Bicalutamide is a weak inhibitor, so the effect is expected to be small.
How serious is the interaction between Bicalutamide and Sparsentan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change; monitor blood pressure, potassium, edema and liver and kidney function as routinely required for sparsentan.
What other medicines interact with Bicalutamide?
MediHelp also lists interactions of Bicalutamide with, for example, Lomitapide, Aminolevulinic acid, Eliglustat. The full list is on the Bicalutamide page.
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