Drug interactions
Bicalutamide + Voclosporin
Severity: Moderate
Bicalutamide and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin is a CYP3A4 substrate with a narrow therapeutic window, and higher exposure raises nephrotoxicity, hypertension and hyperkalemia. Bicalutamide is only a weak inhibitor, so the effect is likely modest.
What this interaction means in plain words
Bicalutamide and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bicalutamide belongs to Endocrine; Voclosporin belongs to Miscellaneous.
Why it happens
Possible weak inhibition of CYP3A4-mediated voclosporin metabolism by bicalutamide.
What to do
Monitor eGFR, blood pressure and potassium, and reduce voclosporin dose if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bicalutamide
- Bicalutamide + Lomitapide Major
- Aminolevulinic acid + Bicalutamide Moderate
- Bicalutamide + Eliglustat Moderate
- Bicalutamide + Flibanserin Moderate
- Bicalutamide + Ivosidenib Moderate
- Bicalutamide + Lonafarnib Moderate
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Bicalutamide with Voclosporin?
MediHelp rates the interaction as moderate. Bicalutamide and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin is a CYP3A4 substrate with a narrow therapeutic window, and higher exposure raises nephrotoxicity, hypertension and hyperkalemia. Bicalutamide is only a weak inhibitor, so the effect is likely modest.
How serious is the interaction between Bicalutamide and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor eGFR, blood pressure and potassium, and reduce voclosporin dose if renal function declines.
What other medicines interact with Bicalutamide?
MediHelp also lists interactions of Bicalutamide with, for example, Lomitapide, Aminolevulinic acid, Eliglustat. The full list is on the Bicalutamide page.
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