Drug interactions
Bicalutamide + Warfarin
Severity: Moderate
Bicalutamide and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bicalutamide may displace warfarin from plasma proteins and has been reported to increase the anticoagulant effect. This can lead to a higher INR and bleeding risk.
What this interaction means in plain words
Bicalutamide and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bicalutamide belongs to Endocrine; Warfarin belongs to Cardiovascular.
Why it happens
Possible protein binding displacement of warfarin and in vitro inhibition of CYP2C9.
What to do
Monitor INR closely when bicalutamide is started or stopped. Adjust warfarin dose if INR rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Other interactions of Bicalutamide
- Bicalutamide + Lomitapide Major
- Aminolevulinic acid + Bicalutamide Moderate
- Bicalutamide + Eliglustat Moderate
- Bicalutamide + Flibanserin Moderate
- Bicalutamide + Ivosidenib Moderate
- Bicalutamide + Lonafarnib Moderate
Frequently asked questions
Can I take Bicalutamide with Warfarin?
MediHelp rates the interaction as moderate. Bicalutamide and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bicalutamide may displace warfarin from plasma proteins and has been reported to increase the anticoagulant effect. This can lead to a higher INR and bleeding risk.
How serious is the interaction between Bicalutamide and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR closely when bicalutamide is started or stopped. Adjust warfarin dose if INR rises.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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