Drug interactions
Bictegravir + Sucralfate
Severity: Moderate
Bictegravir and Sucralfate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sucralfate contains aluminium, which can bind bictegravir in the gut and reduce its absorption. This may lower bictegravir exposure and risk virologic failure and resistance.
What this interaction means in plain words
Bictegravir and Sucralfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chelation of bictegravir by polyvalent cations (aluminium) in the gastrointestinal tract, reducing absorption.
What to do
Take bictegravir at least 2 hours before sucralfate under fasting conditions, and avoid taking them together or sucralfate shortly before bictegravir. Consider an alternative gastroprotective agent if separation is not feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sucralfate
Frequently asked questions
Can I take Bictegravir with Sucralfate?
MediHelp rates the interaction as moderate. Bictegravir and Sucralfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sucralfate contains aluminium, which can bind bictegravir in the gut and reduce its absorption. This may lower bictegravir exposure and risk virologic failure and resistance.
How serious is the interaction between Bictegravir and Sucralfate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take bictegravir at least 2 hours before sucralfate under fasting conditions, and avoid taking them together or sucralfate shortly before bictegravir. Consider an alternative gastroprotective agent if separation is not feasible.
What other medicines interact with Sucralfate?
MediHelp also lists interactions of Sucralfate with, for example, Ciprofloxacin, Gemifloxacin, Levofloxacin. The full list is on the Sucralfate page.
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