Drug interactions
Levofloxacin + Sucralfate
Severity: Major
Levofloxacin and Sucralfate: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sucralfate reduces levofloxacin absorption through aluminum chelation, which can lower antibiotic exposure and risk treatment failure.
What this interaction means in plain words
Levofloxacin and Sucralfate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Levofloxacin belongs to Anti Bacterial; Sucralfate belongs to Gastrointestinal Tract.
Why it happens
Chelation of levofloxacin by aluminum in sucralfate reduces gastrointestinal absorption.
What to do
Give levofloxacin at least 2 hours before or 2 hours after sucralfate. Use an alternative if separation is not feasible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sucralfate
- Ciprofloxacin + Sucralfate Major
- Gemifloxacin + Sucralfate Major
- Moxifloxacin + Sucralfate Major
- Nalidixic Acid + Sucralfate Major
- Ofloxacin + Sucralfate Major
- Bictegravir + Sucralfate Moderate
Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Frequently asked questions
Can I take Levofloxacin with Sucralfate?
MediHelp rates the interaction as major. Levofloxacin and Sucralfate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sucralfate reduces levofloxacin absorption through aluminum chelation, which can lower antibiotic exposure and risk treatment failure.
How serious is the interaction between Levofloxacin and Sucralfate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give levofloxacin at least 2 hours before or 2 hours after sucralfate. Use an alternative if separation is not feasible.
What other medicines interact with Sucralfate?
MediHelp also lists interactions of Sucralfate with, for example, Ciprofloxacin, Gemifloxacin, Moxifloxacin. The full list is on the Sucralfate page.
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