Drug interactions
Gemifloxacin + Sucralfate
Severity: Major
Gemifloxacin and Sucralfate: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aluminum in sucralfate binds gemifloxacin in the gut and reduces its absorption, which can lead to subtherapeutic antibiotic levels and treatment failure.
What this interaction means in plain words
Gemifloxacin and Sucralfate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Gemifloxacin belongs to Anti Bacterial; Sucralfate belongs to Gastrointestinal Tract.
Why it happens
Chelation of the fluoroquinolone by aluminum in sucralfate reduces oral absorption.
What to do
Give gemifloxacin at least 2 hours before sucralfate. Do not give it within 3 hours after sucralfate.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sucralfate
- Ciprofloxacin + Sucralfate Major
- Levofloxacin + Sucralfate Major
- Moxifloxacin + Sucralfate Major
- Nalidixic Acid + Sucralfate Major
- Ofloxacin + Sucralfate Major
- Bictegravir + Sucralfate Moderate
Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Frequently asked questions
Can I take Gemifloxacin with Sucralfate?
MediHelp rates the interaction as major. Gemifloxacin and Sucralfate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Aluminum in sucralfate binds gemifloxacin in the gut and reduces its absorption, which can lead to subtherapeutic antibiotic levels and treatment failure.
How serious is the interaction between Gemifloxacin and Sucralfate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give gemifloxacin at least 2 hours before sucralfate. Do not give it within 3 hours after sucralfate.
What other medicines interact with Sucralfate?
MediHelp also lists interactions of Sucralfate with, for example, Ciprofloxacin, Levofloxacin, Moxifloxacin. The full list is on the Sucralfate page.
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