Drug interactions
Moxifloxacin + Sucralfate
Severity: Major
Moxifloxacin and Sucralfate: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sucralfate can reduce oral moxifloxacin absorption by forming chelates with aluminum, leading to lower antibiotic levels and possible treatment failure.
What this interaction means in plain words
Moxifloxacin and Sucralfate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Moxifloxacin belongs to Anti Bacterial; Sucralfate belongs to Gastrointestinal Tract.
Why it happens
Chelation of moxifloxacin by aluminum in sucralfate reduces gastrointestinal absorption.
What to do
Give moxifloxacin at least 4 hours before or 8 hours after sucralfate, as labeled for polyvalent cations. Consider alternative therapy if spacing is impractical.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sucralfate
- Ciprofloxacin + Sucralfate Major
- Gemifloxacin + Sucralfate Major
- Levofloxacin + Sucralfate Major
- Nalidixic Acid + Sucralfate Major
- Ofloxacin + Sucralfate Major
- Bictegravir + Sucralfate Moderate
Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Moxifloxacin with Sucralfate?
MediHelp rates the interaction as major. Moxifloxacin and Sucralfate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sucralfate can reduce oral moxifloxacin absorption by forming chelates with aluminum, leading to lower antibiotic levels and possible treatment failure.
How serious is the interaction between Moxifloxacin and Sucralfate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give moxifloxacin at least 4 hours before or 8 hours after sucralfate, as labeled for polyvalent cations. Consider alternative therapy if spacing is impractical.
What other medicines interact with Sucralfate?
MediHelp also lists interactions of Sucralfate with, for example, Ciprofloxacin, Gemifloxacin, Levofloxacin. The full list is on the Sucralfate page.
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