Drug interactions
Ofloxacin + Sucralfate
Severity: Major
Ofloxacin and Sucralfate: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aluminum in sucralfate chelates ofloxacin in the gut and lowers its absorption, risking subtherapeutic antibiotic levels and treatment failure.
What this interaction means in plain words
Ofloxacin and Sucralfate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ofloxacin belongs to Anti Bacterial; Sucralfate belongs to Gastrointestinal Tract.
Why it happens
Chelation of ofloxacin by aluminum in sucralfate reduces oral bioavailability.
What to do
Give ofloxacin at least 2 hours before sucralfate. Use a different antibiotic if separation is not possible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sucralfate
- Ciprofloxacin + Sucralfate Major
- Gemifloxacin + Sucralfate Major
- Levofloxacin + Sucralfate Major
- Moxifloxacin + Sucralfate Major
- Nalidixic Acid + Sucralfate Major
- Bictegravir + Sucralfate Moderate
Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Frequently asked questions
Can I take Ofloxacin with Sucralfate?
MediHelp rates the interaction as major. Ofloxacin and Sucralfate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Aluminum in sucralfate chelates ofloxacin in the gut and lowers its absorption, risking subtherapeutic antibiotic levels and treatment failure.
How serious is the interaction between Ofloxacin and Sucralfate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give ofloxacin at least 2 hours before sucralfate. Use a different antibiotic if separation is not possible.
What other medicines interact with Sucralfate?
MediHelp also lists interactions of Sucralfate with, for example, Ciprofloxacin, Gemifloxacin, Levofloxacin. The full list is on the Sucralfate page.
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