Drug interactions
Bivalirudin + Ticlopidine
Severity: Moderate
Bivalirudin and Ticlopidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bivalirudin is a direct thrombin inhibitor, and ticlopidine inhibits platelet aggregation. Together they increase bleeding tendency, although combined use during coronary intervention has been standard practice.
What this interaction means in plain words
Bivalirudin and Ticlopidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects of direct thrombin inhibition and P2Y12 platelet inhibition.
What to do
Monitor for access-site and systemic bleeding and check hemoglobin as indicated. Keep bivalirudin infusion no longer than the procedure needs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ticlopidine
Frequently asked questions
Can I take Bivalirudin with Ticlopidine?
MediHelp rates the interaction as moderate. Bivalirudin and Ticlopidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bivalirudin is a direct thrombin inhibitor, and ticlopidine inhibits platelet aggregation. Together they increase bleeding tendency, although combined use during coronary intervention has been standard practice.
How serious is the interaction between Bivalirudin and Ticlopidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for access-site and systemic bleeding and check hemoglobin as indicated. Keep bivalirudin infusion no longer than the procedure needs.
What other medicines interact with Ticlopidine?
MediHelp also lists interactions of Ticlopidine with, for example, Mavacamten, Abrocitinib, Acetylsalicylic acid. The full list is on the Ticlopidine page.
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