Drug interactions
Bleomycin + Palifermin
Severity: Moderate
Bleomycin and Palifermin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palifermin stimulates epithelial cell growth, which may make rapidly dividing mucosal cells more vulnerable to cytotoxic drugs. When given close to chemotherapy, it worsened and prolonged oral mucositis.
What this interaction means in plain words
Bleomycin and Palifermin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bleomycin belongs to Oncology; Palifermin belongs to Miscellaneous.
Why it happens
Palifermin-driven epithelial proliferation increases the sensitivity of mucosa to cytotoxic chemotherapy.
What to do
Do not give palifermin within 24 hours before, during, or within 24 hours after bleomycin. Follow the labeled scheduling around chemotherapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bleomycin
- Adenovirus types 4 and 7 live + Bleomycin Contraindicated
- Bleomycin + Brentuximab Contraindicated
- Bleomycin + Brentuximab vedotin Contraindicated
- Bleomycin + Dengue vaccine Major
- Bleomycin + Trastuzumab deruxtecan Major
- Bleomycin + Cholera vaccine Moderate
Other interactions of Palifermin
Frequently asked questions
Can I take Bleomycin with Palifermin?
MediHelp rates the interaction as moderate. Bleomycin and Palifermin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Palifermin stimulates epithelial cell growth, which may make rapidly dividing mucosal cells more vulnerable to cytotoxic drugs. When given close to chemotherapy, it worsened and prolonged oral mucositis.
How serious is the interaction between Bleomycin and Palifermin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give palifermin within 24 hours before, during, or within 24 hours after bleomycin. Follow the labeled scheduling around chemotherapy.
What other medicines interact with Bleomycin?
MediHelp also lists interactions of Bleomycin with, for example, Adenovirus types 4 and 7 live, Brentuximab, Brentuximab vedotin. The full list is on the Bleomycin page.
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