Drug interactions
Bleomycin + Trastuzumab
Severity: Minor
Bleomycin and Trastuzumab: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trastuzumab increases neutropenia when added to myelosuppressive chemotherapy, but bleomycin is relatively marrow-sparing. Any additive effect is likely small, and the main shared concern is pulmonary toxicity, which both agents can cause rarely.
What this interaction means in plain words
Bleomycin and Trastuzumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bleomycin belongs to Oncology; Trastuzumab belongs to Oncology.
Why it happens
Possible additive hematologic and pulmonary toxicity; no specific pharmacokinetic mechanism.
What to do
Monitor blood counts and respiratory symptoms; evaluate new cough or dyspnea promptly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bleomycin
- Adenovirus types 4 and 7 live + Bleomycin Contraindicated
- Bleomycin + Brentuximab Contraindicated
- Bleomycin + Brentuximab vedotin Contraindicated
- Bleomycin + Dengue vaccine Major
- Bleomycin + Trastuzumab deruxtecan Major
- Bleomycin + Cholera vaccine Moderate
Other interactions of Trastuzumab
Frequently asked questions
Can I take Bleomycin with Trastuzumab?
MediHelp rates the interaction as minor. Bleomycin and Trastuzumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Trastuzumab increases neutropenia when added to myelosuppressive chemotherapy, but bleomycin is relatively marrow-sparing. Any additive effect is likely small, and the main shared concern is pulmonary toxicity, which both agents can cause rarely.
How serious is the interaction between Bleomycin and Trastuzumab?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and respiratory symptoms; evaluate new cough or dyspnea promptly.
What other medicines interact with Bleomycin?
MediHelp also lists interactions of Bleomycin with, for example, Adenovirus types 4 and 7 live, Brentuximab, Brentuximab vedotin. The full list is on the Bleomycin page.
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