Drug interactions
Bortezomib + Bosentan
Severity: Moderate
Bortezomib and Bosentan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan is a moderate CYP3A4 inducer and bortezomib is partly metabolized by CYP3A4, so bortezomib exposure may be reduced. The clinical significance is uncertain but reduced efficacy is possible.
What this interaction means in plain words
Bortezomib and Bosentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bortezomib belongs to Oncology; Bosentan belongs to Miscellaneous.
Why it happens
Bosentan induces CYP3A4, increasing bortezomib metabolism.
What to do
Monitor disease response and consider an alternative to bosentan if loss of bortezomib efficacy is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bortezomib with Bosentan?
MediHelp rates the interaction as moderate. Bortezomib and Bosentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan is a moderate CYP3A4 inducer and bortezomib is partly metabolized by CYP3A4, so bortezomib exposure may be reduced. The clinical significance is uncertain but reduced efficacy is possible.
How serious is the interaction between Bortezomib and Bosentan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor disease response and consider an alternative to bosentan if loss of bortezomib efficacy is suspected.
What other medicines interact with Bortezomib?
MediHelp also lists interactions of Bortezomib with, for example, Apalutamide, Carbamazepine, Etrasimod. The full list is on the Bortezomib page.
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