Drug interactions
Bortezomib + Chloramphenicol
Severity: Moderate
Bortezomib and Chloramphenicol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol may raise bortezomib concentrations by inhibiting its CYP3A4 metabolism. Both drugs can also cause myelosuppression, so toxicity such as thrombocytopenia and neuropathy may increase.
What this interaction means in plain words
Bortezomib and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bortezomib belongs to Oncology; Chloramphenicol belongs to Anti Bacterial.
Why it happens
CYP3A4 inhibition reducing bortezomib clearance, plus additive bone marrow suppression.
What to do
Monitor blood counts and neuropathy symptoms closely. Consider an alternative antibiotic where feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
Frequently asked questions
Can I take Bortezomib with Chloramphenicol?
MediHelp rates the interaction as moderate. Bortezomib and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol may raise bortezomib concentrations by inhibiting its CYP3A4 metabolism. Both drugs can also cause myelosuppression, so toxicity such as thrombocytopenia and neuropathy may increase.
How serious is the interaction between Bortezomib and Chloramphenicol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neuropathy symptoms closely. Consider an alternative antibiotic where feasible.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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