Drug interactions
Bortezomib + Cimetidine
Severity: Minor
Bortezomib and Cimetidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine may modestly increase bortezomib exposure. This could theoretically worsen neuropathy, thrombocytopenia and gastrointestinal toxicity.
What this interaction means in plain words
Bortezomib and Cimetidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bortezomib belongs to Oncology; Cimetidine belongs to Gastrointestinal Tract.
Why it happens
Cimetidine weakly inhibits CYP3A4, which is involved in bortezomib metabolism.
What to do
No dose adjustment is required routinely. Monitor for neuropathy and blood counts.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
Frequently asked questions
Can I take Bortezomib with Cimetidine?
MediHelp rates the interaction as minor. Bortezomib and Cimetidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cimetidine may modestly increase bortezomib exposure. This could theoretically worsen neuropathy, thrombocytopenia and gastrointestinal toxicity.
How serious is the interaction between Bortezomib and Cimetidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required routinely. Monitor for neuropathy and blood counts.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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