Drug interactions
Bortezomib + Clopidogrel
Severity: Moderate
Bortezomib and Clopidogrel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bortezomib commonly causes thrombocytopenia, which adds to the bleeding risk of clopidogrel's platelet inhibition. Any CYP2C19-related effect of bortezomib is minor and less relevant than the platelet effect.
What this interaction means in plain words
Bortezomib and Clopidogrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bortezomib belongs to Oncology; Clopidogrel belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic bleeding risk from drug-induced thrombocytopenia and P2Y12 inhibition.
What to do
Check platelet counts regularly and reassess the need for clopidogrel if counts fall to low levels; monitor for bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bortezomib and Clopidogrel, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Clopidogrel
Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
Frequently asked questions
Can I take Bortezomib with Clopidogrel?
MediHelp rates the interaction as moderate. Bortezomib and Clopidogrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bortezomib commonly causes thrombocytopenia, which adds to the bleeding risk of clopidogrel's platelet inhibition. Any CYP2C19-related effect of bortezomib is minor and less relevant than the platelet effect.
How serious is the interaction between Bortezomib and Clopidogrel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check platelet counts regularly and reassess the need for clopidogrel if counts fall to low levels; monitor for bleeding.
What other medicines interact with Clopidogrel?
MediHelp also lists interactions of Clopidogrel with, for example, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Abrocitinib, Acetylsalicylic acid. The full list is on the Clopidogrel page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
