Drug interactions
Bortezomib + Dutasteride-tamsulosin
Severity: Minor
Bortezomib and Dutasteride-tamsulosin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bortezomib has been shown to be a weak CYP2D6 inhibitor in vitro, and no clinically significant effect on tamsulosin is established. Bortezomib itself can cause hypotension, so additive blood pressure effects are possible.
What this interaction means in plain words
Bortezomib and Dutasteride-tamsulosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bortezomib belongs to Oncology; Dutasteride-tamsulosin belongs to Genitourinary.
Why it happens
Weak in vitro CYP2D6 inhibition; clinical relevance is not established.
What to do
No dose change is needed. Monitor blood pressure and orthostatic symptoms during bortezomib treatment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dutasteride-tamsulosin
Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
Frequently asked questions
Can I take Bortezomib with Dutasteride-tamsulosin?
MediHelp rates the interaction as minor. Bortezomib and Dutasteride-tamsulosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bortezomib has been shown to be a weak CYP2D6 inhibitor in vitro, and no clinically significant effect on tamsulosin is established. Bortezomib itself can cause hypotension, so additive blood pressure effects are possible.
How serious is the interaction between Bortezomib and Dutasteride-tamsulosin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Monitor blood pressure and orthostatic symptoms during bortezomib treatment.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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