Drug interactions
Bortezomib + Isavuconazonium
Severity: Moderate
Bortezomib and Isavuconazonium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole is a moderate CYP3A4 inhibitor, so it is more likely to raise bortezomib levels than the reverse. Bortezomib is not known to meaningfully increase isavuconazole levels. The practical concern is increased bortezomib toxicity.
What this interaction means in plain words
Bortezomib and Isavuconazonium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bortezomib belongs to Oncology; Isavuconazonium belongs to Anti Fungals.
Why it happens
Isavuconazole inhibits CYP3A4, reducing bortezomib clearance; bortezomib is not an established inhibitor of CYP3A4.
What to do
Monitor for bortezomib adverse effects such as neuropathy, cytopenias and gastrointestinal toxicity, and reduce the dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Bortezomib with Isavuconazonium?
MediHelp rates the interaction as moderate. Bortezomib and Isavuconazonium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isavuconazole is a moderate CYP3A4 inhibitor, so it is more likely to raise bortezomib levels than the reverse. Bortezomib is not known to meaningfully increase isavuconazole levels. The practical concern is increased bortezomib toxicity.
How serious is the interaction between Bortezomib and Isavuconazonium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bortezomib adverse effects such as neuropathy, cytopenias and gastrointestinal toxicity, and reduce the dose if they occur.
What other medicines interact with Bortezomib?
MediHelp also lists interactions of Bortezomib with, for example, Apalutamide, Carbamazepine, Etrasimod. The full list is on the Bortezomib page.
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