Drug interactions
Bortezomib + Lapatinib
Severity: Moderate
Bortezomib and Lapatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib inhibits CYP3A4 and may increase bortezomib exposure. This could increase neuropathy, thrombocytopenia and gastrointestinal toxicity.
What this interaction means in plain words
Bortezomib and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bortezomib belongs to Oncology; Lapatinib belongs to Oncology.
Why it happens
Lapatinib inhibits CYP3A4, a pathway of bortezomib metabolism.
What to do
Monitor for peripheral neuropathy, platelet counts and gastrointestinal effects. Reduce or hold bortezomib if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bortezomib and Lapatinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
Frequently asked questions
Can I take Bortezomib with Lapatinib?
MediHelp rates the interaction as moderate. Bortezomib and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib inhibits CYP3A4 and may increase bortezomib exposure. This could increase neuropathy, thrombocytopenia and gastrointestinal toxicity.
How serious is the interaction between Bortezomib and Lapatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for peripheral neuropathy, platelet counts and gastrointestinal effects. Reduce or hold bortezomib if toxicity appears.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
