Drug interactions
Bortezomib + Lenacapavir
Severity: Moderate
Bortezomib and Lenacapavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A4 inhibitor with a very long residual effect after subcutaneous dosing. It may raise bortezomib exposure and increase toxicity such as neuropathy and thrombocytopenia.
What this interaction means in plain words
Bortezomib and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bortezomib belongs to Oncology; Lenacapavir belongs to Anti Virals.
Why it happens
Lenacapavir inhibits CYP3A4, reducing the metabolic clearance of bortezomib.
What to do
Monitor for bortezomib toxicity, including neuropathy and blood counts, and reduce the bortezomib dose if adverse effects develop. Keep in mind the effect may persist for months after the last lenacapavir injection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Bortezomib with Lenacapavir?
MediHelp rates the interaction as moderate. Bortezomib and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenacapavir is a moderate CYP3A4 inhibitor with a very long residual effect after subcutaneous dosing. It may raise bortezomib exposure and increase toxicity such as neuropathy and thrombocytopenia.
How serious is the interaction between Bortezomib and Lenacapavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bortezomib toxicity, including neuropathy and blood counts, and reduce the bortezomib dose if adverse effects develop. Keep in mind the effect may persist for months after the last lenacapavir injection.
What other medicines interact with Bortezomib?
MediHelp also lists interactions of Bortezomib with, for example, Apalutamide, Carbamazepine, Etrasimod. The full list is on the Bortezomib page.
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