Drug interactions
Bortezomib + Mifepristone
Severity: Moderate
Bortezomib and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone may inhibit CYP3A4 and increase bortezomib exposure, raising the risk of neuropathy, thrombocytopenia and gastrointestinal toxicity.
What this interaction means in plain words
Bortezomib and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bortezomib belongs to Oncology; Mifepristone belongs to Endocrine.
Why it happens
CYP3A4 inhibition by mifepristone reduces bortezomib metabolism.
What to do
Monitor for peripheral neuropathy and blood counts, and reduce the bortezomib dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
Frequently asked questions
Can I take Bortezomib with Mifepristone?
MediHelp rates the interaction as moderate. Bortezomib and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone may inhibit CYP3A4 and increase bortezomib exposure, raising the risk of neuropathy, thrombocytopenia and gastrointestinal toxicity.
How serious is the interaction between Bortezomib and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for peripheral neuropathy and blood counts, and reduce the bortezomib dose if toxicity occurs.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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