Drug interactions
Bortezomib + Oliceridine
Severity: Minor
Bortezomib and Oliceridine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bortezomib is reported to inhibit CYP2D6 weakly in vitro, so any effect on oliceridine exposure is likely small. Additive sedation could occur, and opioids can worsen bortezomib-related constipation and neuropathy symptoms.
What this interaction means in plain words
Bortezomib and Oliceridine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bortezomib belongs to Oncology; Oliceridine belongs to Musculoskeletal.
Why it happens
Bortezomib may weakly inhibit CYP2D6, which could modestly reduce oliceridine clearance.
What to do
Monitor for sedation and respiratory depression, and titrate oliceridine to effect.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Bortezomib with Oliceridine?
MediHelp rates the interaction as minor. Bortezomib and Oliceridine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bortezomib is reported to inhibit CYP2D6 weakly in vitro, so any effect on oliceridine exposure is likely small. Additive sedation could occur, and opioids can worsen bortezomib-related constipation and neuropathy symptoms.
How serious is the interaction between Bortezomib and Oliceridine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and respiratory depression, and titrate oliceridine to effect.
What other medicines interact with Bortezomib?
MediHelp also lists interactions of Bortezomib with, for example, Apalutamide, Carbamazepine, Etrasimod. The full list is on the Bortezomib page.
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