Drug interactions
Bortezomib + Verapamil
Severity: Moderate
Bortezomib and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil, a moderate CYP3A4 inhibitor, may increase bortezomib exposure, potentially worsening neuropathy, thrombocytopenia and gastrointestinal toxicity. The effect with moderate inhibitors is less pronounced than with strong inhibitors.
What this interaction means in plain words
Bortezomib and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bortezomib belongs to Oncology; Verapamil belongs to Cardiovascular.
Why it happens
Verapamil inhibits CYP3A4, reducing bortezomib metabolism.
What to do
Monitor for bortezomib toxicity, including peripheral neuropathy and blood counts, and reduce the dose if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
Frequently asked questions
Can I take Bortezomib with Verapamil?
MediHelp rates the interaction as moderate. Bortezomib and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil, a moderate CYP3A4 inhibitor, may increase bortezomib exposure, potentially worsening neuropathy, thrombocytopenia and gastrointestinal toxicity. The effect with moderate inhibitors is less pronounced than with strong inhibitors.
How serious is the interaction between Bortezomib and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bortezomib toxicity, including peripheral neuropathy and blood counts, and reduce the dose if adverse effects emerge.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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