Drug interactions
Bosentan + Brexpiprazole
Severity: Moderate
Bosentan and Brexpiprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan is a weak to moderate CYP3A4 inducer and may lower brexpiprazole exposure. Reduced exposure could weaken antipsychotic or antidepressant-augmentation effect. The effect is smaller than with strong inducers.
What this interaction means in plain words
Bosentan and Brexpiprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Brexpiprazole belongs to Central Nervous System.
Why it happens
Bosentan induces CYP3A4, increasing the metabolic clearance of brexpiprazole.
What to do
Monitor clinical response to brexpiprazole after bosentan is started and increase the dose if symptoms re-emerge. Re-evaluate the dose when bosentan is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Brexpiprazole?
MediHelp rates the interaction as moderate. Bosentan and Brexpiprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan is a weak to moderate CYP3A4 inducer and may lower brexpiprazole exposure. Reduced exposure could weaken antipsychotic or antidepressant-augmentation effect. The effect is smaller than with strong inducers.
How serious is the interaction between Bosentan and Brexpiprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to brexpiprazole after bosentan is started and increase the dose if symptoms re-emerge. Re-evaluate the dose when bosentan is stopped.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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