Drug interactions
Bosentan + Brigatinib
Severity: Moderate
Bosentan and Brigatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan is a moderate CYP3A4 inducer and can lower brigatinib exposure. Reduced brigatinib levels may compromise control of ALK-positive lung cancer.
What this interaction means in plain words
Bosentan and Brigatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Brigatinib belongs to Oncology.
Why it happens
Induction of CYP3A4 by bosentan increases brigatinib metabolism.
What to do
Prefer an alternative to bosentan where possible. If coadministration is unavoidable, monitor tumour response closely; labeling for moderate inducers suggests considering brigatinib dose increases only under specialist guidance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Other interactions of Brigatinib
Frequently asked questions
Can I take Bosentan with Brigatinib?
MediHelp rates the interaction as moderate. Bosentan and Brigatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan is a moderate CYP3A4 inducer and can lower brigatinib exposure. Reduced brigatinib levels may compromise control of ALK-positive lung cancer.
How serious is the interaction between Bosentan and Brigatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative to bosentan where possible. If coadministration is unavoidable, monitor tumour response closely; labeling for moderate inducers suggests considering brigatinib dose increases only under specialist guidance.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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