Drug interactions
Bosentan + Bromocriptine
Severity: Moderate
Bosentan and Bromocriptine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan is a moderate CYP3A4 inducer and may lower bromocriptine concentrations, since bromocriptine is extensively metabolized by CYP3A4. Reduced dopaminergic effect, such as loss of prolactin suppression or symptom control, may occur.
What this interaction means in plain words
Bosentan and Bromocriptine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Bromocriptine belongs to Central Nervous System.
Why it happens
Bosentan induces CYP3A4, increasing the first-pass and systemic metabolism of bromocriptine.
What to do
Monitor prolactin levels or symptom control and increase the bromocriptine dose if the response weakens. Reassess the dose if bosentan is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bromocriptine
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Bromocriptine?
MediHelp rates the interaction as moderate. Bosentan and Bromocriptine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan is a moderate CYP3A4 inducer and may lower bromocriptine concentrations, since bromocriptine is extensively metabolized by CYP3A4. Reduced dopaminergic effect, such as loss of prolactin suppression or symptom control, may occur.
How serious is the interaction between Bosentan and Bromocriptine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor prolactin levels or symptom control and increase the bromocriptine dose if the response weakens. Reassess the dose if bosentan is stopped.
What other medicines interact with Bromocriptine?
MediHelp also lists interactions of Bromocriptine with, for example, Amisulpride, Atazanavir, Cobicistat. The full list is on the Bromocriptine page.
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