Drug interactions
Bosentan + Capmatinib
Severity: Moderate
Bosentan and Capmatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan may reduce capmatinib concentrations through enzyme induction. Subtherapeutic capmatinib exposure may reduce efficacy in MET-driven lung cancer.
What this interaction means in plain words
Bosentan and Capmatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Capmatinib belongs to Oncology.
Why it happens
Bosentan induces CYP3A4, which contributes to capmatinib metabolism.
What to do
Avoid the combination if possible, since strong inducers are to be avoided and moderate inducers have a lesser but similar effect. Monitor tumour response if bosentan is necessary.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Other interactions of Capmatinib
- Amobarbital + Capmatinib Major
- Apalutamide + Capmatinib Major
- Capmatinib + Carbamazepine Major
- Capmatinib + Efavirenz Major
- Capmatinib + Enzalutamide Major
- Capmatinib + Phenytoin Major
Frequently asked questions
Can I take Bosentan with Capmatinib?
MediHelp rates the interaction as moderate. Bosentan and Capmatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan may reduce capmatinib concentrations through enzyme induction. Subtherapeutic capmatinib exposure may reduce efficacy in MET-driven lung cancer.
How serious is the interaction between Bosentan and Capmatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible, since strong inducers are to be avoided and moderate inducers have a lesser but similar effect. Monitor tumour response if bosentan is necessary.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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