Drug interactions
Bosentan + Cinacalcet
Severity: Moderate
Bosentan and Cinacalcet: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan induces CYP3A4 and may lower cinacalcet exposure. Reduced cinacalcet effect could lead to inadequate suppression of parathyroid hormone and less calcium lowering.
What this interaction means in plain words
Bosentan and Cinacalcet can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Cinacalcet belongs to Miscellaneous.
Why it happens
Bosentan induction of CYP3A4 increases the metabolism of cinacalcet.
What to do
Monitor serum calcium and parathyroid hormone after starting or stopping bosentan and increase the cinacalcet dose if the response is reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cinacalcet
- Cinacalcet + Etelcalcetide Contraindicated
- Cinacalcet + Eliglustat Major
- Cinacalcet + Metoclopramide Major
- Cinacalcet + Metoclopramide intranasal Major
- Cinacalcet + Tamoxifen Major
- Abiraterone + Cinacalcet Moderate
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Cinacalcet?
MediHelp rates the interaction as moderate. Bosentan and Cinacalcet can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan induces CYP3A4 and may lower cinacalcet exposure. Reduced cinacalcet effect could lead to inadequate suppression of parathyroid hormone and less calcium lowering.
How serious is the interaction between Bosentan and Cinacalcet?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and parathyroid hormone after starting or stopping bosentan and increase the cinacalcet dose if the response is reduced.
What other medicines interact with Cinacalcet?
MediHelp also lists interactions of Cinacalcet with, for example, Etelcalcetide, Eliglustat, Metoclopramide. The full list is on the Cinacalcet page.
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