Drug interactions
Bosentan + Clomipramine
Severity: Minor
Bosentan and Clomipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan is a moderate inducer of CYP3A4 and may modestly lower clomipramine concentrations, which is only one of several pathways for clomipramine metabolism. The clinical impact is probably small, but reduced antidepressant or antiobsessional effect is possible.
What this interaction means in plain words
Bosentan and Clomipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bosentan belongs to Miscellaneous; Clomipramine belongs to Central Nervous System.
Why it happens
Bosentan induces CYP3A4 (and CYP2C9), increasing clomipramine metabolism.
What to do
Monitor clinical response to clomipramine after bosentan is started or stopped. Adjust the dose if efficacy is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Clomipramine?
MediHelp rates the interaction as minor. Bosentan and Clomipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bosentan is a moderate inducer of CYP3A4 and may modestly lower clomipramine concentrations, which is only one of several pathways for clomipramine metabolism. The clinical impact is probably small, but reduced antidepressant or antiobsessional effect is possible.
How serious is the interaction between Bosentan and Clomipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to clomipramine after bosentan is started or stopped. Adjust the dose if efficacy is lost.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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