Drug interactions
Bosentan + Clorazepate
Severity: Minor
Bosentan and Clorazepate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan is a CYP3A4 inducer and may speed the metabolism of clorazepate's active metabolite, reducing its effect. This could weaken anxiolytic or anticonvulsant control, although the clinical impact is likely modest.
What this interaction means in plain words
Bosentan and Clorazepate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bosentan belongs to Miscellaneous; Clorazepate belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 by bosentan increases clearance of nordiazepam, the active metabolite of clorazepate.
What to do
Watch for reduced clinical response to clorazepate after bosentan is started and increase the dose if needed. Reassess the dose if bosentan is discontinued.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Clorazepate?
MediHelp rates the interaction as minor. Bosentan and Clorazepate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bosentan is a CYP3A4 inducer and may speed the metabolism of clorazepate's active metabolite, reducing its effect. This could weaken anxiolytic or anticonvulsant control, although the clinical impact is likely modest.
How serious is the interaction between Bosentan and Clorazepate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for reduced clinical response to clorazepate after bosentan is started and increase the dose if needed. Reassess the dose if bosentan is discontinued.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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