Drug interactions
Bosentan + Daridorexant
Severity: Moderate
Bosentan and Daridorexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan, a moderate CYP3A4 inducer, can reduce daridorexant exposure. Insomnia control may be diminished.
What this interaction means in plain words
Bosentan and Daridorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Daridorexant belongs to Central Nervous System.
Why it happens
CYP3A4 induction by bosentan increases daridorexant metabolism.
What to do
Avoid coadministration with moderate inducers per labeling, or monitor for reduced hypnotic effect and consider an alternative sleep agent.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Other interactions of Daridorexant
Frequently asked questions
Can I take Bosentan with Daridorexant?
MediHelp rates the interaction as moderate. Bosentan and Daridorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan, a moderate CYP3A4 inducer, can reduce daridorexant exposure. Insomnia control may be diminished.
How serious is the interaction between Bosentan and Daridorexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration with moderate inducers per labeling, or monitor for reduced hypnotic effect and consider an alternative sleep agent.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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