Drug interactions
Bosentan + Dronabinol
Severity: Minor
Bosentan and Dronabinol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan induces CYP3A4 and CYP2C9, both of which metabolize dronabinol. Dronabinol exposure may fall, potentially reducing its effect on nausea or appetite.
What this interaction means in plain words
Bosentan and Dronabinol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bosentan belongs to Miscellaneous; Dronabinol belongs to Central Nervous System.
Why it happens
Bosentan induces CYP3A4 and CYP2C9, increasing dronabinol metabolism.
What to do
Monitor for reduced dronabinol efficacy and titrate the dose upward if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Other interactions of Dronabinol
- Cefotetan + Dronabinol Contraindicated
- Disulfiram + Dronabinol Contraindicated
- Dronabinol + Midazolam intranasal Major
- Dronabinol + Zuranolone Major
- Amobarbital + Dronabinol Moderate
- Apalutamide + Dronabinol Moderate
Frequently asked questions
Can I take Bosentan with Dronabinol?
MediHelp rates the interaction as minor. Bosentan and Dronabinol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bosentan induces CYP3A4 and CYP2C9, both of which metabolize dronabinol. Dronabinol exposure may fall, potentially reducing its effect on nausea or appetite.
How serious is the interaction between Bosentan and Dronabinol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced dronabinol efficacy and titrate the dose upward if needed.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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