Drug interactions
Bosentan + Eliglustat
Severity: Moderate
Bosentan and Eliglustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat depends on CYP2D6 and CYP3A4 for clearance, so CYP3A inducers can lower its levels. Bosentan, a moderate inducer, may reduce its efficacy in Gaucher disease.
What this interaction means in plain words
Bosentan and Eliglustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Eliglustat belongs to Miscellaneous.
Why it happens
Bosentan induces CYP3A4, increasing eliglustat metabolism.
What to do
Monitor clinical response to eliglustat and consider alternative therapy if bosentan is required long-term.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Bosentan with Eliglustat?
MediHelp rates the interaction as moderate. Bosentan and Eliglustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eliglustat depends on CYP2D6 and CYP3A4 for clearance, so CYP3A inducers can lower its levels. Bosentan, a moderate inducer, may reduce its efficacy in Gaucher disease.
How serious is the interaction between Bosentan and Eliglustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to eliglustat and consider alternative therapy if bosentan is required long-term.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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