Drug interactions
Bosentan + Eslicarbazepine
Severity: Moderate
Bosentan and Eslicarbazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan is metabolized by CYP3A4 and CYP2C9, so eslicarbazepine may lower bosentan exposure and reduce its effect on pulmonary hypertension. The magnitude is likely modest.
What this interaction means in plain words
Bosentan and Eslicarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Eslicarbazepine belongs to Central Nervous System.
Why it happens
CYP3A4 induction by eslicarbazepine increases bosentan metabolism.
What to do
Monitor clinical response and functional status of pulmonary hypertension; adjust therapy if efficacy declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Eslicarbazepine?
MediHelp rates the interaction as moderate. Bosentan and Eslicarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan is metabolized by CYP3A4 and CYP2C9, so eslicarbazepine may lower bosentan exposure and reduce its effect on pulmonary hypertension. The magnitude is likely modest.
How serious is the interaction between Bosentan and Eslicarbazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and functional status of pulmonary hypertension; adjust therapy if efficacy declines.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Mavacamten, Rilpivirine, Artemether / lumefantrine. The full list is on the Eslicarbazepine page.
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