Drug interactions
Bosentan + Etravirine
Severity: Moderate
Bosentan and Etravirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan induces CYP3A4 and CYP2C9, and etravirine is cleared by both, so etravirine exposure may fall. Reduced etravirine levels risk loss of virologic suppression and resistance. Etravirine, being an inducer too, may also lower bosentan exposure.
What this interaction means in plain words
Bosentan and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Etravirine belongs to Anti Virals.
Why it happens
Bosentan induces CYP3A4 and CYP2C9, increasing the metabolism of etravirine.
What to do
Monitor HIV viral load and clinical response, and watch for reduced bosentan efficacy in pulmonary hypertension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Bosentan with Etravirine?
MediHelp rates the interaction as moderate. Bosentan and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan induces CYP3A4 and CYP2C9, and etravirine is cleared by both, so etravirine exposure may fall. Reduced etravirine levels risk loss of virologic suppression and resistance. Etravirine, being an inducer too, may also lower bosentan exposure.
How serious is the interaction between Bosentan and Etravirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor HIV viral load and clinical response, and watch for reduced bosentan efficacy in pulmonary hypertension.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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