Drug interactions
Bosentan + Ivacaftor
Severity: Moderate
Bosentan and Ivacaftor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
CYP3A4 inducers can markedly decrease ivacaftor exposure and may cause loss of CFTR modulator efficacy. Bosentan is a moderate inducer, so reduction is likely less than with strong inducers like rifampin but still relevant.
What this interaction means in plain words
Bosentan and Ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Ivacaftor belongs to Miscellaneous.
Why it happens
Bosentan induces CYP3A4, increasing ivacaftor metabolism.
What to do
Monitor lung function and clinical response to ivacaftor. Avoid strong inducers and consider an alternative to bosentan.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bosentan and Ivacaftor, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Other interactions of Ivacaftor
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
Frequently asked questions
Can I take Bosentan with Ivacaftor?
MediHelp rates the interaction as moderate. Bosentan and Ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. CYP3A4 inducers can markedly decrease ivacaftor exposure and may cause loss of CFTR modulator efficacy. Bosentan is a moderate inducer, so reduction is likely less than with strong inducers like rifampin but still relevant.
How serious is the interaction between Bosentan and Ivacaftor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor lung function and clinical response to ivacaftor. Avoid strong inducers and consider an alternative to bosentan.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
